US 7719274 Method of obtaining a magnetic resonance image in which the streak artifacts
A non-linear phase correction method is provided. For the non-linear phase correction method, image information is acquired by gradient echo echo planar imaging (EPI). Reference information is acquired by spin echo EPI. The image information is corrected based on the reference information.
US 7746070 Method for generating high resolution MRI image and recording medium thereof
The present invention relates to a high-resolution magnetic resonance imaging (MRI) image generating method using a new MRI image method called a generalized series parallel imaging technique, and a recording medium thereof. In the high-resolution MRI image generating method using the generalized series parallel imaging technique according to the…
Disclosed are (i) a boron-dipyrrin compound having thienyl groups, (ii) a preparation method thereof and (iii) a chemosensor comprising the boron-dipyrrin compound having thienyl groups. More particularly, the present invention provides a boron-dipyrrin compound having thienyl group, furyl (OC4H3) group or selyl (SeC4H3) group, which is…
US 8018582 Simultaneous Detection Apparatus of Raman and Light Scattering
Provided is a detection apparatus of Raman scattering and light scattering, and more particularly, a simultaneous detection apparatus of Raman scattering and dynamic light scattering and a detection method using the same. The simultaneous detection apparatus of Raman scattering and light scattering includes: a detection unit for applying incident…
Disclosed herein are methods of diagnosing, preventing and treating Alzheimer’s disease based on the use of an inhibitor for the binding of amyloid-.beta. (A.beta.) to Fc.gamma.RIIb, and a method of screening the inhibitor. The inhibitor is selected from the group consisting of an Fc.gamma.RIIb protein or a variant thereof, an Fc.gamma.RIIb…
This invention is about a method for the prenatal diagnosis of preterm delivery, fetal infection, and fetal damage, and diagnostic reagent system and diagnostic kit for the diagnosis. The method, diagnostic reagent system, and kit are based on the finding that the level of MMP-8 in the amniotic fluid is significantly higher when the pregnant woman…
US 7482134 Signals and Molecular Species Involved in Senescence
The present invention relates to (a) a method for detecting a senescent cell, which comprises measuring a relative alteration to young cell in a signal or molecular species involved in signal transduction; (b) a method; and (c) a composition for modulating cellular senescence comprising treating a senescent cell with the effective amount of an…
The present invention relates to fluorinated benzothiazole derivatives, a preparation method thereof, and an imaging agent for diagnosing Alzheimer’s disease using the same, and more particularly to fluorinated benzothiazole derivatives represented by Chemical Formula 1, derivatives of Chemical Formula 2 as a starting material for preparation…
Disclosed are a barb-wired single crystalline silicon micro needle and a biopsy method and a medicine injecting method using the same. The micro needle comprises a main body part, at least one extension part formed on a side surface of the main body part, and a protrusion part protruded from both side surfaces of the extension part. A medicine…
US 8795196 Three-dimensional Micro Spike and Method of Manufacturing the same
A micro spike having a three-dimensional structure made of single crystalline silicon and being capable of picking an enough amount of a tissue to examine the tissue while minimizing an examinee’s pain with a minimal invasion when picking the tissue and a method of manufacturing the same are disclosed. The micro spike comprising: a main body part;…
The present invention relates generally to an electric non-contact apparatus and method for taking electrocardiograms and, more particularly, to an electric non-contact apparatus and method for taking electrocardiograms, in which an examinee can have an electrocardiogram taken in a comfortable position because the apparatus and method are applied…
The present invention relates to a bone graft material and a scaffold for tissue engineering applications, which have an osteogenesis-promoting peptide immobilized on the surface. More particularly, the invention relates to a bone graft material and a scaffold for tissue engineering applications, which have a cell adhesion-inducing peptide and/or…
US 7927289 Catheter Capable of being Equipped with Micro Biopsy Tool
Disclosed is a catheter used to pick a sample of a lesion cell tissue existing in the living body, and more particularly a catheter capable of freely coupling or separating a micro biopsy tool and picking a tissue required for an examination just by inserting and extracting the biopsy tool into and from a lesion region when picking the tissue. The…
The present invention relates to a method for expanding adult stem cells and progenitor cells in blood by inducing human blood-derived blood cell mass using cell coagulation, which is a technique of using monocytic blood cells to effectively culture and proliferate adult stem cells and progenitor cells.
Disclosed is a method for monitoring depletion of high-abundance and/or recovery of low-abundance proteins from blood in real time.
US 9057725 Composition for Diagnosing, Treating, and Preventing Liver Disease
Liver disease diagnosis and substance screening through the measurement of TM4SF5 expression level, and liver disease prevention and/or treatment through the use of an antagonist for TM4SF5.
The tricarbonyl technetium-99m or rhenium-188 labeled ring RGD derivative has a high subnanomolar affinity to αvβ3 integrin, and is useful as a medicine for the diagnosis or treatment of angiogenesis-related diseases.
The present invention relates to a duplex vibriocidal assay capable of simultaneously measuring vibriocidal serum antibody titer with respect to each serotype when a combined Vibrio vaccine prepared by mixing two or more kinds of strains is evaluated after the combined vaccine is administrated.
PCT KR2011-008314 Method for Diagnosing Stomach Cancer
The present invention relates to a simple and effective method for diagnosing stomach cancer by measuring the level of soluble truncated c-Met protein in a biological sample.
The present invention relates to surface-modified tantalum oxide nanoparticles and a contrast medium for X-ray computed tomography and a highly dielectric thin film using the same.
The present invention relates to a recombinant vector and to transgenic mice expressing human ferritin in a manner non-specific to tissue.
PCT KR2009-007186 Gene which Enhances Resistance to Plant Pathogens and use thereof
The present invention relates to a Capsicum annuum-derived CaRLK1 for enhancing resistance to plant pathogens.
EP 2524926 Anticancer Peptide Sequence
The present invention relates to an anticancer peptide originating from a RORα derivative. The anticancer peptide can be used to treat and prevent cancer, particularly prostate cancer and colorectal cancer.
PCT KR2010-006295 Single Domain Antibody against MUC1
The present invention relates to a single domain antibody (nanoscale antibody or NanoMAb) comprising CDRs of MUC1 for the treatment or dignosis of cancer.
US App 2014-0170078 T2 MRI Contrast Agent for Cell Contrast and Preparation thereof
T2 MRI contrast agent for cell contrast, comprising magnetic nanoparticles with ferrimagnetism at room temperature.
US 7650113 Apparatus for receiving wide-band pulse signal in communication channel
Disclosed herein is an apparatus for receiving a wide-band pulse signal in a communication channel using a human body. When a weak wide-band pulse signal, which is output from a communication channel using a human body as a data transmission medium, is restored to a digital signal, it is possible to accomplish low power consumption and high data…
US 7719274 Method of obtaining a magnetic resonance image in which the streak artifacts
A non-linear phase correction method is provided. For the non-linear phase correction method, image information is acquired by gradient echo echo planar imaging (EPI). Reference information is acquired by spin echo EPI. The image information is corrected based on the reference information.
The present invention relates to a method for simultaneously surface expressing a target protein using a cofactor and an enzyme regenerating the cofactor on the cell surface. According to the present invention, it is possible to provide a microorganism capable of simultaneously surface expressing a target protein using a cofactor to transform a…
US 6623729 Sustained release drug delivery
The present invention relates to a process of preparing a sustained release micelle by copolymerizing a biodegradable polyester hydrophobic polymer and a hydrophilic polyethylene glycol (PEG) to obtain a block copolymer, reacting the block copolymer with a linker to the hydroxyl group of the block copolymer and conjugating the linker-bound block…
US 6596521 Method for manufacturing organic acid by high-efficiency continuous fermentation
The present invention provides a method for manufacturing organic acid by high-efficiency fermentation, which comprises the steps of continuous culture of organic acid bacteria and collection of organic acid produced from the culture employing a cell-recycle multiple-stage continuous fermentor with serially connected fermentors, each of which…
US 6943022 Inhibition of Apoptosis by the Expression of Antisense RNA of Caspase-3
The present invention relates to an antisense nucleotide of caspase-3, an expression vector encoding antisense RNA of caspase-3, and an inhibition method of cellular apoptosis in recombinant Chinese hamster ovary (CHO) cells using the same. More precisely, the present invention relates to an antisense nucleotide composed of a base sequence…
US 7148334 Composition for protecting proteins degradation comprising small heat shock
The present invention relates to a composition containing sHSPs for prevention of protein degradation and a composition for two-dimensional (2-D) gel electrophoresis. Furthermore, the present invention relates to the improved method of 2-D gel electrophoresis, which is characterized by using sHSPs. According to the present invention, decreasing of…
US 7309586 Chimeric Coiled Coil Molecules
The present application describes a fusion molecule that includes coiled coil domain, which renders the molecule soluble and provides potent activity.
US 7183087 Process for Preparing Polyhydroxyalkanoate Employing maoC Gene
The present invention relates to a method for producing middle-chain-length polyhydroxyalkanoate (MCL-PHA) using a maoC gene. The producing method of MCL-PHA according to the present invention comprises the steps of transforming a microorganism with the maoC gene to give a transformant, the microorganism being deleted of a fadB gene and containing…
US 7348402 Antimicrobial peptide, its analogs and antimicrobial composition comprising them
Disclosed is a novel antimicrobial peptide having excellent antimicrobial activities, its analogs and an antimicrobial composition comprising them. The antimicrobial peptide alternatively comprises basic amino acid residues and hydrophobic amino acid residues, and is able to penetrate into microbial cells and act against a wide variety of…
US 7470770 Gene encoding malic enzyme and method for preparing succinic acid using the same
A nucleotide sequence encoding a malic enzyme and a method for preparing succinic acid using the same, more particularly, a maeB nucleotide sequence encoding a malic enzyme B having the activity of converting pyruvic acid or pyruvate to malic acid or malate, or vice versa, a recombinant vector containing the gene, a microorganism transformed with…
US 7491528 Method for extracellular production of target proteins employing OmpF in E. coli
The present invention provides an expression vector comprising genes encoding OmpF of E. coli and a desired protein, E.coli transformed with the expression vector, and a method for extracellular production of desired proteins by employing the same. The recombinant expression vector of the invention comprises an ampicillin-resistance gene, the OmpF…
US 7595156 Genes for Synthesis of FR-008 Polyketides
The present invention relates to the base sequence of whole genes involved in the biosynthesis of FR-008 polyketides derived from Streptomyces sp. FR-008. This base sequence comprises genes coding for ketosynthase (KS), acyl transferase (AT), acyl carrier protein (ACP), ketoreductase (KR), dehydratase (DH) and enoyl reductase (ER) domains, and…
US 7588934 Gene Encoding Fumarate Hydratase C and use thereof
A nucleotide sequence encoding a fumarate hydratase C and a method for preparing succinic acid using the same, more particularly, a fumarate hydratase C having the activity of converting malate to fumarate, a fumC nucleotide sequence encoding the fumarate hydratase C, a recombinant vector containing the nucleotide sequence, a microorganism…
US 7737828 Tactile Feedback Device
The present invention discloses a tactile feedback device for giving realistic touch sensation to the user by stimulating the skin of the user. The tactile feedback device of the present invention comprises a housing having one end positioned near the skin of the user in use, an actuator, touch pins and an elastic means. The actuator is mounted…
US 7659064 PNA Chip using Zip-codes and Fabrication Method thereof
A PNA zip-code chip in which PNA zip-code probes are immobilized on a substrate at high density using an epoxy compound as a linker, and method for fabricating such PNA chip. The use of PNA provides the chip with superior properties to DNA chips, allowing precise diagnosis of congenital diseases or base mutations with much higher sensitivity than…
US 7745218 Genome Minimization by tn5-coupled cre/loxP Excision System
Disclosed is a method for developing novel strains deleted specific chromosome sites, using transposon and Cre/loxP site-specific recombination by Cre expression vector, wherein the transposon comprises a selectable marker and loxP site.
US 6316594 Antimicrobial peptide isolated from parasilurus asotus and its uses
Disclosed is a novel antimicrobial peptide, named parasin I, which is isolated from catfish. Catfish produce a strong antimicrobial peptide in the epithelial mucosal layer upon epidermal injury to protect against the invasion of microorganisms. It is 2000.4 Da in molecular mass and consist of 19 amino acid residues, represented by…
US 8067552 Method for preparing a target protein using the sHSPs
The present invention relates to a method for separating and purifying a target protein, a method for preparing a target protein, and a method for bioconversion by a whole cell enzyme or a partially purified enzyme. According to the present invention, when the sHSPs are added in cultivation, separation and purification processes for preparing a…
Disclosed are (i) a boron-dipyrrin compound having thienyl groups, (ii) a preparation method thereof and (iii) a chemosensor comprising the boron-dipyrrin compound having thienyl groups. More particularly, the present invention provides a boron-dipyrrin compound having thienyl group, furyl (OC4H3) group or selyl (SeC4H3) group, which is…
Mechanisms regulating cell proliferation stop and differentiation initiation during the development stage of mammalian embryo, and the proteins involved therein, are presented. Differentiation regulators, methods of regulating differentiation, transgenic organisms with loss of expression of the differentiation regulator, and methods of preparing…
The present invention relates to a method for secreting and producing a target protein into cell culture broth. More particularly, the invention relates to a microorganism co-transformed with a recombinant expression vector containing E. coli outer membrane protein F (OmpF) and a recombinant expression vector containing a target protein to be…
US 7517654 Peptide and a derivative thereof promoting cell adhesion and spreading
The present invention relates to a peptide promoting cell adhesion and spreading, fragments, and derivatives thereof, more particularly, integrin-α3β1-dependent peptide in human laminin-5 α3 chain LG3 domain, mediating integrin α3β1 binding and cell adhesion and spreading, fragments and derivatives thereof. The inventive peptide, fragments…
Disclosed herein are methods of diagnosing, preventing and treating Alzheimer’s disease based on the use of an inhibitor for the binding of amyloid-.beta. (A.beta.) to Fc.gamma.RIIb, and a method of screening the inhibitor. The inhibitor is selected from the group consisting of an Fc.gamma.RIIb protein or a variant thereof, an Fc.gamma.RIIb…
The present invention provides a process for preparing thiazole derivatives of formula (XI), that activate the delta subtype of the human Peroxisome Proliferator Activated Receptor (hPPAR.delta.), and also provides processes for compounds of formula (VI), (VII), (VIII) and (IX), intermediate compounds for preparation of the above compounds of…
US 7482134 Signals and Molecular Species Involved in Senescence
The present invention relates to (a) a method for detecting a senescent cell, which comprises measuring a relative alteration to young cell in a signal or molecular species involved in signal transduction; (b) a method; and (c) a composition for modulating cellular senescence comprising treating a senescent cell with the effective amount of an…
US 7001769 Nucleic Acid Sequences and Proteins Involved in Cellular Senescence
The present invention relates to nucleic acid sequences and proteins involved in senescence and particularly, to nucleic acid sequences and proteins including amphiphysin and caveolin involved in cellular senescence and their use.
US 6590139 Method for Producing Cloned Cows
The present invention provides a method for producing cloned cows by employing in vitro maturation of oocytes and nuclear transfer techniques. The method comprises collecting donor somatic cell lines from cows; maturing oocytes extracted from an ovary in vitro; enucleating the oocyte by cutting a portion of the zona pellucida and squeezing out a…
This invention is about a method for the prenatal diagnosis of preterm delivery, fetal infection, and fetal damage, and diagnostic reagent system and diagnostic kit for the diagnosis. The method, diagnostic reagent system, and kit are based on the finding that the level of MMP-8 in the amniotic fluid is significantly higher when the pregnant woman…
US 7947435 Neuronal Regeneration Material Screening Method by ex vivo Model
The present invention relates to a neuronal regeneration material screening method using ex vivo models, more precisely a neuronal regeneration material screening method using an organotypic spinal cord slice culture. The neuronal regeneration material screening method using spinal cord slices of living bodies of the present invention can be…
The present invention relates to a novel environmental stress-resistant transcription factor and a method for enhancing the environmental stress resistance of plants using the same. More particularly, the invention relates to an environmental stress-resistant transcription factor isolated from barley and a method for enhancing the environmental…
The present invention relates to a gene controlling the flowering time of plants, and a method for manipulating the flowering time of plants using the gene. More particularly, the present invention relates to a LOV1 gene controlling the flowering time of plants, which is isolated from Arabidopsis thaliana, and also to a method for either delaying…
US 7728194 DNA Fragment Specific to Cytoplasmic Male Sterile Ppepper and use thereof
The present invention relates to a DNA fragment specific to a cytoplasmic male sterile pepper comprising a polynucleotide of SEQ ID NO: 1, a candidate polynucleotide (named orf456) associated with cytoplasmic male sterile pepper consisting of a 223.sup.rd to 678.sup.th nucleic acid of SEQ ID NO:1, and a polynucleotide of SEQ ID NO: 2. The DNA…
US App 20070055072 Process for Preparing Guggulsterones and Guggulsterol
The present invention relates to a method for selective preparing 4,17 (20)-E-pregnadiene-3,16-dione (E-guggul-sterone) of the formula (III) and 4,17 (20)-Z-pregnadiene-3,16-dione (Z-guggulsterone) of the formula (IV) having an effect of lowering the elevated low density lipoprotein (LDL) and high levels of the cholesterol effectively, and…
The invention relates to root-specific expansin gene to regulating root growth and obstacle-touching stress resistance in the plant, and more particularly to a root growth regulating gene, GmEXP1, isolated from soybean (Glycine max), an expansin polypeptide encoded by the gene and a method for enhancing root growth of plants by overexpression of…
The present invention provides a process for preparing thiazole derivatives of formula (XI), that activate the delta subtype of the human Peroxisome Proliferator Activated Receptor (hPPAR.delta.), and also provides processes for compounds of formula (VI), (VII), (VIII) and (IX), intermediate compounds for preparation of the above compounds of…
US 7001769 Nucleic Acid Sequences and Proteins Involved in Cellular Senescence
The present invention relates to nucleic acid sequences and proteins involved in senescence and particularly, to nucleic acid sequences and proteins including amphiphysin and caveolin involved in cellular senescence and their use.
US 6590139 Method for Producing Cloned Cows
The present invention provides a method for producing cloned cows by employing in vitro maturation of oocytes and nuclear transfer techniques. The method comprises collecting donor somatic cell lines from cows; maturing oocytes extracted from an ovary in vitro; enucleating the oocyte by cutting a portion of the zona pellucida and squeezing out a…
A technique for inhibiting biofouling caused by biofilms grown on a material surface of a water system where microorganisms exist such as the membrane surface of a membrane bioreactor (MBR) for advanced wastewater treatment is disclosed. Specifically, a magnetic carrier comprising an enzyme for quenching quorum sensing that inhibits biofilm…
The present invention relates to a novel function of lysyl tRNA synthetase (KRS) which enhances tumor cell migration and affects cancer metastasis via KRS’s interaction with laminin receptor (67LR) by its translocation to membrane. More particularly, the present invention relates to a method for modulating cancer metastasis or migration, which…
US 8795196 Three-dimensional Micro Spike and Method of Manufacturing the same
A micro spike having a three-dimensional structure made of single crystalline silicon and being capable of picking an enough amount of a tissue to examine the tissue while minimizing an examinee’s pain with a minimal invasion when picking the tissue and a method of manufacturing the same are disclosed. The micro spike comprising: a main body part;…
US 8683957 Movement Analysis Device for Rodents
A movement analysis device for rodents capable of variably adjusting a space where a rodent is placed in order to stimulate the behavior of the rodent so that motor functions of the rodent can be analyzed more effectively, The movement analysis device for rodents includes a body including a pair of side plates distanced from each other with a…
US 8124832 Method for Producing Cloned Dog
Provided is a method for producing a cloned dog by enucleating an oocyte of a dog to produce an enucleated oocyte, transferring a somatic cell of the dog into the enucleated oocyte, carrying out electrofusion under optimized conditions to produce a nuclear transfer embryo, and transferring the nuclear transfer embryo into its surrogate…
The present invention relates to a screening method for RNA specific binding peptide using alpha-helical peptides. The screening method for RNA specific binding peptide of the present invention using alpha-helical peptides enables the selection of a peptide having strong binding capacity to a specific RNA having particular morphology and…
The present invention relates to a bone graft material and a scaffold for tissue engineering applications, which have an osteogenesis-promoting peptide immobilized on the surface. More particularly, the invention relates to a bone graft material and a scaffold for tissue engineering applications, which have a cell adhesion-inducing peptide and/or…
US 6912900 Muscular Motion Simulating System
Disclosed herein is a muscular motion simulating system that is capable of simulating a force-displacement characteristic of an ideal muscle model through the use of a large displacement magnetic actuating unit supported by means of linear springs. The muscular motion simulating system comprises a base plate mounted to a virtual muscle part in a…
DNA analysis device/method/PCR quantitative detecting device using nanopore structure.
PCT KR2011-003008 Nanofluidic Fluorescence Apertureless Near-field Scanning Optical Microscope
A fluorescence apertureless near-field scanning optical microscope which is capable of focusing outputs of fluorescence signals to a specific direction.
PCT KR2011-007119 Conductive Bio-nano Fusion Chain and Method for Preparing same
A multifunctional photoconductive bio-nano fusion chain, which is formed by linearly arranging a conductive nanoparticle chain in a non-conductrive alpha-synuclein amyloid fibrilsand a method for preparing same.
The present invention relates to a method for expanding adult stem cells and progenitor cells in blood by inducing human blood-derived blood cell mass using cell coagulation, which is a technique of using monocytic blood cells to effectively culture and proliferate adult stem cells and progenitor cells.
PCT KR2011-005146 DNA Double Helical Structure Model
A DNA double helical structure model of the present invention comprises a plurality of nucleotide members capable of being coupled to or being separated from each other.
The present invention relates to a sensor for detecting a target virus and a genotype of the same, and for analysis of mutation site of the target virus at the same time.
Disclosed is a method for monitoring depletion of high-abundance and/or recovery of low-abundance proteins from blood in real time.
US 9057725 Composition for Diagnosing, Treating, and Preventing Liver Disease
Liver disease diagnosis and substance screening through the measurement of TM4SF5 expression level, and liver disease prevention and/or treatment through the use of an antagonist for TM4SF5.
The present invention relates to a thiol derivative of biotin, and an analysis method of the substrate specificity of a serine/threonine kinase using the same.
PCT KR2010-008711 Composition for Analyzing the Pluripotency of Pig Stem Cells
The present invention relates to a composition for analyzing the pluripotency of pig stem cells comprising an agent for measuring the expression level of pig NANOG protein.
The present invention relates to a composition for predicting chance of brain tumor recurrence and survival prognosis, and can be effectively used to increase the survival rate of patients with brain tumor recurrence.
PCT KR2011-002193 Composition for Predicting Prognosis of Breast Cancer, and Kit Containing same
A composition for predicting the prognosis of breast cancer, containing a medicine for measuring the expression level of a marker gene for predicting the prognosis of breast cancer, a kit containing the composition for predicting the prognosis of breast cancer, and a method for providing the information necessary for predicting prognosis including…
PCT KR2009-007186 Gene which Enhances Resistance to Plant Pathogens and use thereof
The present invention relates to a Capsicum annuum-derived CaRLK1 for enhancing resistance to plant pathogens.
The present invention relates to a method for removing β2-microglobulin (β2M) in blood at a neutral pH by using a fibril of a peptide having the 58th to 67th amino acid sequence of β2M.
The present invention relates to a miRNA regulating the insulin signaling pathway, and to a method for screening a material for controlling the action of a target gene thereof for promoting cell growth.
US 7719274 Method of obtaining a magnetic resonance image in which the streak artifacts
A non-linear phase correction method is provided. For the non-linear phase correction method, image information is acquired by gradient echo echo planar imaging (EPI). Reference information is acquired by spin echo EPI. The image information is corrected based on the reference information.
US 7746070 Method for generating high resolution MRI image and recording medium thereof
The present invention relates to a high-resolution magnetic resonance imaging (MRI) image generating method using a new MRI image method called a generalized series parallel imaging technique, and a recording medium thereof. In the high-resolution MRI image generating method using the generalized series parallel imaging technique according to the…
US 6692531 Prosthetic stem with cement sleeve
An artificial joint is capable of harmoniously connecting the artificial joint, cement and a bone and facilitating effusion of the cement at the time of implantation, as well as diminishing the stress applied thereto. The artificial joint includes a head, a neck and a stem, the stem being coated in advance with cement so as to easily bond the…
US 6623729 Sustained release drug delivery
The present invention relates to a process of preparing a sustained release micelle by copolymerizing a biodegradable polyester hydrophobic polymer and a hydrophilic polyethylene glycol (PEG) to obtain a block copolymer, reacting the block copolymer with a linker to the hydroxyl group of the block copolymer and conjugating the linker-bound block…
Disclosed herewith is a prosthetic foot. The prosthetic foot is to be connected to a pylon that is utilized for the substitution of the shinbone of an amputee. The prosthetic foot includes an ankle portion to be secured to the pylon. A plurality of curved portions are extended from one end of the ankle portion. A sole portion is extended from one…
US 6524344 Cement Coverings in Artificial Joint Stems and Systems
A cement jacket for a cemented artificial joint stem, the cement jacket including a main body with a hollow interior and an open upper end for receiving and enclosing at least a part of a stem of an artificial joint, the cement jacket being shaped and adapted for longitudinal insertion in an opening formed in a bone canal of a human body, the…
US 6497728 Metal jacket for a cementless artificial joint stem and artificial joint stem
The present invention is intended to provide a metal jacket for a cementless artificial joint stem, wherein shear force detrimental to the service life of an artificial joint can be markedly reduced and stress shielding phenomena can also be markedly relieved, due to the construction of the metal jacket which can be fixed to the bone and can…
Disclosed are (i) a boron-dipyrrin compound having thienyl groups, (ii) a preparation method thereof and (iii) a chemosensor comprising the boron-dipyrrin compound having thienyl groups. More particularly, the present invention provides a boron-dipyrrin compound having thienyl group, furyl (OC4H3) group or selyl (SeC4H3) group, which is…
US 7482134 Signals and Molecular Species Involved in Senescence
The present invention relates to (a) a method for detecting a senescent cell, which comprises measuring a relative alteration to young cell in a signal or molecular species involved in signal transduction; (b) a method; and (c) a composition for modulating cellular senescence comprising treating a senescent cell with the effective amount of an…
A bone graft substitute using magnesium substituted calcium phosphate compounds and a method of manufacturing the same is provided in which the bone graft substitute is used for recovering bones damaged due to a bone fracture. The method of manufacturing a bone graft substitute includes the steps of mixing powdered calcium pyrophosphate and a…
Disclosed are a barb-wired single crystalline silicon micro needle and a biopsy method and a medicine injecting method using the same. The micro needle comprises a main body part, at least one extension part formed on a side surface of the main body part, and a protrusion part protruded from both side surfaces of the extension part. A medicine…
The present invention relates to a novel function of lysyl tRNA synthetase (KRS) which enhances tumor cell migration and affects cancer metastasis via KRS’s interaction with laminin receptor (67LR) by its translocation to membrane. More particularly, the present invention relates to a method for modulating cancer metastasis or migration, which…
US 8003093 B cell-based vaccine loaded with the ligand of natural killer T cell and antigen
The present invention relates to a B cell-based vaccine loaded with the ligand of natural killer T cell and antigen for the prevention and treatment of disease, more precisely, an immunotherapeutic and prophylactic vaccine mediated by B cells loaded with .alpha.-galactosylceramide, a kind of glycolipid which can stimulate natural killer T cells. A…
The present invention relates to a screening method for RNA specific binding peptide using alpha-helical peptides. The screening method for RNA specific binding peptide of the present invention using alpha-helical peptides enables the selection of a peptide having strong binding capacity to a specific RNA having particular morphology and…
The present invention relates generally to an electric non-contact apparatus and method for taking electrocardiograms and, more particularly, to an electric non-contact apparatus and method for taking electrocardiograms, in which an examinee can have an electrocardiogram taken in a comfortable position because the apparatus and method are applied…
The present invention relates to a bone graft material and a scaffold for tissue engineering applications, which have an osteogenesis-promoting peptide immobilized on the surface. More particularly, the invention relates to a bone graft material and a scaffold for tissue engineering applications, which have a cell adhesion-inducing peptide and/or…
US 7927289 Catheter Capable of being Equipped with Micro Biopsy Tool
Disclosed is a catheter used to pick a sample of a lesion cell tissue existing in the living body, and more particularly a catheter capable of freely coupling or separating a micro biopsy tool and picking a tissue required for an examination just by inserting and extracting the biopsy tool into and from a lesion region when picking the tissue. The…
US 6912900 Muscular Motion Simulating System
Disclosed herein is a muscular motion simulating system that is capable of simulating a force-displacement characteristic of an ideal muscle model through the use of a large displacement magnetic actuating unit supported by means of linear springs. The muscular motion simulating system comprises a base plate mounted to a virtual muscle part in a…
Disclosed is a deodorizer composition comprising magnesium and calcium phosphate compounds, capable of effectively removing various malodorous components from the atmosphere.
US App 20130030325 Amniotic Fluid Collector
An amniotic fluid collector which is configured to be inserted and positioned inside the uterus of a pregnant woman.
US App 20130066263 Microjet Drug Delivery System and Microjet Injector
A microjet drug delivery system that injects by microjet spraying a drug solution.
A method for simultaneously detecting fluorescence/raman signals and a medical imaging device using the method.
US App 20130137944 Method for Coating a Medical Product with a Pharmaceutical Substance
The present invention relates to a method for coating a medical product with a sticky gel-type pharmaceutical substance, which can be easily applied on a silk or polypropylene product.
Disclosed is a method for monitoring depletion of high-abundance and/or recovery of low-abundance proteins from blood in real time.
The present invention relates to a composition for predicting chance of brain tumor recurrence and survival prognosis, and can be effectively used to increase the survival rate of patients with brain tumor recurrence.
PCT KR2011-002193 Composition for Predicting Prognosis of Breast Cancer, and Kit Containing same
A composition for predicting the prognosis of breast cancer, containing a medicine for measuring the expression level of a marker gene for predicting the prognosis of breast cancer, a kit containing the composition for predicting the prognosis of breast cancer, and a method for providing the information necessary for predicting prognosis including…
US App 20140005600 Drug Delivery System Comprising Layered-structure
The present invention relates to a drug delivery system to control the rate and amount of the released drug in a body comprising the layered-structure wherein drug layers and bio-degradable polymer layers are alternately layered.
The present invention relates to surface-modified tantalum oxide nanoparticles and a contrast medium for X-ray computed tomography and a highly dielectric thin film using the same.
US App 20140170078 T2 MRI Contrast Agent for Cell Contrast and Preparation thereof
T2 MRI contrast agent for cell contrast, comprising magnetic nanoparticles with ferrimagnetism at room temperature.
PCT KR2009-002941 Micro Calorimeter Device with Improved Accuracy
A micro calorimeter device with improved accuracy having a new design based on a silicon nitride thin platform implemented with a Nano Electro-Mechanical System(NEMS) processing technology.
US 6692531 Prosthetic stem with cement sleeve
An artificial joint is capable of harmoniously connecting the artificial joint, cement and a bone and facilitating effusion of the cement at the time of implantation, as well as diminishing the stress applied thereto. The artificial joint includes a head, a neck and a stem, the stem being coated in advance with cement so as to easily bond the…
US 6623729 Sustained release drug delivery
The present invention relates to a process of preparing a sustained release micelle by copolymerizing a biodegradable polyester hydrophobic polymer and a hydrophilic polyethylene glycol (PEG) to obtain a block copolymer, reacting the block copolymer with a linker to the hydroxyl group of the block copolymer and conjugating the linker-bound block…
Disclosed herewith is a prosthetic foot. The prosthetic foot is to be connected to a pylon that is utilized for the substitution of the shinbone of an amputee. The prosthetic foot includes an ankle portion to be secured to the pylon. A plurality of curved portions are extended from one end of the ankle portion. A sole portion is extended from one…
US 7348402 Antimicrobial peptide, its analogs and antimicrobial composition comprising them
Disclosed is a novel antimicrobial peptide having excellent antimicrobial activities, its analogs and an antimicrobial composition comprising them. The antimicrobial peptide alternatively comprises basic amino acid residues and hydrophobic amino acid residues, and is able to penetrate into microbial cells and act against a wide variety of…
US 6524344 Cement Coverings in Artificial Joint Stems and Systems
A cement jacket for a cemented artificial joint stem, the cement jacket including a main body with a hollow interior and an open upper end for receiving and enclosing at least a part of a stem of an artificial joint, the cement jacket being shaped and adapted for longitudinal insertion in an opening formed in a bone canal of a human body, the…
US 6497728 Metal jacket for a cementless artificial joint stem and artificial joint stem
The present invention is intended to provide a metal jacket for a cementless artificial joint stem, wherein shear force detrimental to the service life of an artificial joint can be markedly reduced and stress shielding phenomena can also be markedly relieved, due to the construction of the metal jacket which can be fixed to the bone and can…
US 6316594 Antimicrobial peptide isolated from parasilurus asotus and its uses
Disclosed is a novel antimicrobial peptide, named parasin I, which is isolated from catfish. Catfish produce a strong antimicrobial peptide in the epithelial mucosal layer upon epidermal injury to protect against the invasion of microorganisms. It is 2000.4 Da in molecular mass and consist of 19 amino acid residues, represented by…
The present invention relates to a gene construct which is capable of achieving efficient production of an antimicrobial peptide in a microorganism, and a method for efficient mass production and separation of an antimicrobial peptide using the same. The gene construct of the present invention has a translationally coupled configuration of two…
US 7517654 Peptide and a derivative thereof promoting cell adhesion and spreading
The present invention relates to a peptide promoting cell adhesion and spreading, fragments, and derivatives thereof, more particularly, integrin-α3β1-dependent peptide in human laminin-5 α3 chain LG3 domain, mediating integrin α3β1 binding and cell adhesion and spreading, fragments and derivatives thereof. The inventive peptide, fragments…
A bone graft substitute using magnesium substituted calcium phosphate compounds and a method of manufacturing the same is provided in which the bone graft substitute is used for recovering bones damaged due to a bone fracture. The method of manufacturing a bone graft substitute includes the steps of mixing powdered calcium pyrophosphate and a…
US 8084399 Pocess for Screening of a Binding Amphiphilic Peptides Specific for Haiprin RNA
The present invention relates to a screening method of an amphiphilic peptide specifically binding to hairpin RNA, more precisely a screening method of an amphiphilic peptide having specificity and strong binding strength to target hairpin RNA using peptide library comprising those peptides having modifications of both hydrophilic face and…
US 7947435 Neuronal Regeneration Material Screening Method by ex vivo Model
The present invention relates to a neuronal regeneration material screening method using ex vivo models, more precisely a neuronal regeneration material screening method using an organotypic spinal cord slice culture. The neuronal regeneration material screening method using spinal cord slices of living bodies of the present invention can be…
US 7960345 Angiogenesis Inhibitor Comprising Meteorin as an Active Ingredient
The present invention relates to an angiogenesis inhibitor comprising meteorin as an active ingredient that is highly expressed in astrocytes of the brain and retina in the late embryonic stage and after the birth of a mouse. It is in particular highly detected in astrocyte endfeet surrounding blood vessels and promotes the expression of…
US 7476540 Monoclonal Antibodies to Mesenchymal Stem Cells
The present invention relates to monoclonal antibodies specifically binding to a membrane antigen of human mesenchymal stem cells, hybridoma cell lines producing the same, and methods for identifying or isolating human mesenchymal stem cells using the same. The monoclonal antibodies of this invention exhibit excellent specificity to human…
US 7482134 Signals and Molecular Species Involved in Senescence
The present invention relates to (a) a method for detecting a senescent cell, which comprises measuring a relative alteration to young cell in a signal or molecular species involved in signal transduction; (b) a method; and (c) a composition for modulating cellular senescence comprising treating a senescent cell with the effective amount of an…
A bone graft substitute using magnesium substituted calcium phosphate compounds and a method of manufacturing the same is provided in which the bone graft substitute is used for recovering bones damaged due to a bone fracture. The method of manufacturing a bone graft substitute includes the steps of mixing powdered calcium pyrophosphate and a…
Disclosed is a composition for treating dementia including shRNA to inhibit expression of S100a9. More particularly, the present disclosure describes a composition for prevention or treatment of dementia which includes shRNA having a nucleotide sequence defined by SEQ. ID No. 1 or 2 or a mixture thereof wherein the nucleotide sequence is…
Disclosed are a barb-wired single crystalline silicon micro needle and a biopsy method and a medicine injecting method using the same. The micro needle comprises a main body part, at least one extension part formed on a side surface of the main body part, and a protrusion part protruded from both side surfaces of the extension part. A medicine…
The present invention relates to a novel function of lysyl tRNA synthetase (KRS) which enhances tumor cell migration and affects cancer metastasis via KRS’s interaction with laminin receptor (67LR) by its translocation to membrane. More particularly, the present invention relates to a method for modulating cancer metastasis or migration, which…
US 7897722 Composition of Bone Formation with PHSRN-RGD Containing Oligopeptide
A PHSRN-RGD-containing oligopeptide and a composition for promoting bone formation, which contains such oligopeptide as an effective ingredient. The oligopeptide promotes osteoblastic cell adhesion and differentiation and enhances bone regenerative ability, so that the inventive oligopeptide can be effectively used in regenerative treatment of…
US 7902165 Use of AIM3 Acting as a Tumor Suppressor
The present invention relates to novel uses of AIM3 acting as a tumor suppressor, and more particularly to methods for using an AIM3 protein or a nucleic acid encoding the protein to activate ATM or ATR and to treat ATM- or ATR-mediated diseases. The AIM3 protein according to the present invention interacts directly with ATM/ATR so as to activate…
US 8003093 B cell-based vaccine loaded with the ligand of natural killer T cell and antigen
The present invention relates to a B cell-based vaccine loaded with the ligand of natural killer T cell and antigen for the prevention and treatment of disease, more precisely, an immunotherapeutic and prophylactic vaccine mediated by B cells loaded with .alpha.-galactosylceramide, a kind of glycolipid which can stimulate natural killer T cells. A…
US 8066978 Biopolymer and Gene Complex
Disclosed herein is a biopolymer/gene complex for the aerosol delivery of a gene. The biopolymer/gene complex comprises a polyethyleneimine (PEI) having a substitution of glucose for at least a portion of the primary amino groups of the polyethyleneimine, and the content of the polyethyleneimine is 2-4 times the content of the gene. Also,…
The present invention relates to a novel diaminedithiol derivative or a pharmaceutically acceptable salt thereof; radiorhenium or radiotechneticum complex thereof; a composition for treating liver cancer comprising the radiorhenium complex and lipiodol; and, a preparative kit of the composition for treating liver cancer. In the composition…
Disclosed is an inhibitor of replicative senescence of human keratinocytes containing retinoic acid, including all-trans retinoic acid, 3,4-didehydroretinoic acid, and 9-cis retinoic acid, as active ingredients. The retinoic acid plays an important role in extending the in vitro life span and inhibiting replicative senescence of the human mucosal…
PCT KR2010-008690 Absorbable Material, and Implant Fixture and Implant using same
The present invention relates to a nano-hybrid material, an implant fixture and an absorbable implant including same wherein an inorganic nanoparticle substance is dispersed in an organic substance and bonded to the organic substance.
US 9057725 Composition for Diagnosing, Treating, and Preventing Liver Disease
Liver disease diagnosis and substance screening through the measurement of TM4SF5 expression level, and liver disease prevention and/or treatment through the use of an antagonist for TM4SF5.
The tricarbonyl technetium-99m or rhenium-188 labeled ring RGD derivative has a high subnanomolar affinity to αvβ3 integrin, and is useful as a medicine for the diagnosis or treatment of angiogenesis-related diseases.
PCT KR2011-006638 Sesterterpene Compounds and Use thereof
Sesterterpene compounds, to the precursors thereof that are hydrolysable in a living body, or to the pharmaceutically acceptable salts thereof, and also relates to the prevention and treatment efficacy of the sesterterpene compounds with respect to non-insulin dependent diabetes mellitus, diabetic complications, alcoholic,…
EP 2612669 Use of the Fetal Reprogramming of a PPAR δ agonist
The PPAR δ agonist can be used in a pharmaceutical composition for enhancing the endurance of a human and an animal by embryonic/fetal reprogramming, preventing/inhibiting metabolic diseases such as obesity, diabetes, arteriosclerosis and fatty liver, and enhancing memory.
The present invention relates to a composition for the prevention and treatment of fatty liver diseases, comprising serine as an active ingredient.
The present invention relates to antifungal composition showing excellent anti-fungal activity specifically to fungus of Genus Ganoderma.
PCT KR2011-002953 Regulator for Chemokine Expression
The present invention relates to a composition and method for suppressing the expression of chemokines using Fas ligand. The method can be used for controlling inflammatory responses.
US 8506937 Artificial Saliva Comprising Hyaluronic Acid
Provided is artificial saliva including hyaluronic acid (HA) useful for the treatment of xerostomia or oral candidiasis.
Provided is a lipid emulsion having krill oil, and the lipid emulsion can be used independently for oral/parenteral administration or as a daily nutrient.
The present invention is related to a composition comprising the ajoene-abundant garlic extract or ajoene isolated therefrom for treating or preventing the disease caused by over-expression or hyper-activation of LXR-alpha or SREBP-1.
A CDK-inhibiting pyrrolopyrimidinone carboxamide derivative or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition containing same as an active ingredient for preventing or treating liver cell cancer.
PCT KR2010-007547 Composition for Preventing or Treating Cancer, Containing LETM1
The present invention relates to a composition for preventing or treating cancer comprising LETM1 or a gene encoding the same, and the composition can be used as a successful therapeutic approach for inhibiting the proliferation and progression of cancer.
US 20120088731 Method for Treating Parkinson’s Disease Trough the Cntrol of the VDAC1 Protein
The present invention relates to a pharmaceutical composition for treating Parkinson’s disease including a VDAC1 protein controller.The present invention is expected to be capable of providing a method for fundamentally treating Parkinson’s disease by preventing abnormal mitochondrial function and/or restoring same.
A transdermal drug delivery system comprising (i) a bisphosphonate-based drug and (ii) a cationic amine compound linked to the bisphosphonate-based drug via an ionic bond, and a pharmaceutical composition comprising the drug delivery system for preventing or treating a bone disease.
The present invention relates to a phosphatidylinositol 3-kinase activity regulator comprising the fifth zinc finger domain of FOG2 capable of inducing cancer cells to die.
The present invention relates to a composition for preventing, relieving and treating diseases caused by expression or over-activation of LXRα or SREBP-1 such as fatty liver, hypertriglyceridemia, hyperreninemia, renin-induced hypertension, aldosteronism, adrenoleukodystrophy, glomerulosclerosis, proteinuria, renal failure, and the…
US 8716556 Arabidopsis-thaliana-derived MYB96 Gene and a use therefor
The present invention relates to a method for increasing biosynthesis of epicuticular wax of a plant through over-expression of MYB96 gene in a plant cell.
PCT KR2009-007186 Gene which Enhances Resistance to Plant Pathogens and use thereof
The present invention relates to a Capsicum annuum-derived CaRLK1 for enhancing resistance to plant pathogens.
The present invention relates to a method for removing β2-microglobulin (β2M) in blood at a neutral pH by using a fibril of a peptide having the 58th to 67th amino acid sequence of β2M.
The present invention relates to a peptide compound which is prepared on the basis of a C-terminal sequence of TSA56 of Orientia tsutsugamushi, and a pharmaceutical composition for relieving scrub typhus using the same.
EP 2524926Anticancer Peptide Sequence
The present invention relates to an anticancer peptide originating from a RORα derivative. The anticancer peptide can be used to treat and prevent cancer, particularly prostate cancer and colorectal cancer.
PCT KR2010-006295 Single Domain Antibody against MUC1
The present invention relates to a single domain antibody (nanoscale antibody or NanoMAb) comprising CDRs of MUC1 for the treatment or dignosis of cancer.
The present invention relates to a biodegradable polysorbitol-based osmotically active transporter (PSOAT) and a method of gene therapy using the same as a gene delivery carrier.
US App 20130184331 Treatment of Neurodegenerative Diseases by Targeting miRNA
The antisense oligonucleotide of the present invention inhibits the function of miR-206 to greatly increase the levels of BDNF and IGF-1 and to increase the regeneration of synapses, thereby treating neurodegenerative diseases, particularly Alzheimer’s disease.