The present invention relates to a method for simultaneously surface expressing a target protein using a cofactor and an enzyme regenerating the cofactor on the cell surface. According to the present invention, it is possible to provide a microorganism capable of simultaneously surface expressing a target protein using a cofactor to transform a…
US 6623729 Sustained release drug delivery
The present invention relates to a process of preparing a sustained release micelle by copolymerizing a biodegradable polyester hydrophobic polymer and a hydrophilic polyethylene glycol (PEG) to obtain a block copolymer, reacting the block copolymer with a linker to the hydroxyl group of the block copolymer and conjugating the linker-bound block…
US 6596521 Method for manufacturing organic acid by high-efficiency continuous fermentation
The present invention provides a method for manufacturing organic acid by high-efficiency fermentation, which comprises the steps of continuous culture of organic acid bacteria and collection of organic acid produced from the culture employing a cell-recycle multiple-stage continuous fermentor with serially connected fermentors, each of which…
US 6943022 Inhibition of Apoptosis by the Expression of Antisense RNA of Caspase-3
The present invention relates to an antisense nucleotide of caspase-3, an expression vector encoding antisense RNA of caspase-3, and an inhibition method of cellular apoptosis in recombinant Chinese hamster ovary (CHO) cells using the same. More precisely, the present invention relates to an antisense nucleotide composed of a base sequence…
US 7148334 Composition for protecting proteins degradation comprising small heat shock
The present invention relates to a composition containing sHSPs for prevention of protein degradation and a composition for two-dimensional (2-D) gel electrophoresis. Furthermore, the present invention relates to the improved method of 2-D gel electrophoresis, which is characterized by using sHSPs. According to the present invention, decreasing of…
US 7183087 Process for Preparing Polyhydroxyalkanoate Employing maoC Gene
The present invention relates to a method for producing middle-chain-length polyhydroxyalkanoate (MCL-PHA) using a maoC gene. The producing method of MCL-PHA according to the present invention comprises the steps of transforming a microorganism with the maoC gene to give a transformant, the microorganism being deleted of a fadB gene and containing…
US 7348402 Antimicrobial peptide, its analogs and antimicrobial composition comprising them
Disclosed is a novel antimicrobial peptide having excellent antimicrobial activities, its analogs and an antimicrobial composition comprising them. The antimicrobial peptide alternatively comprises basic amino acid residues and hydrophobic amino acid residues, and is able to penetrate into microbial cells and act against a wide variety of…
US 7470770 Gene encoding malic enzyme and method for preparing succinic acid using the same
A nucleotide sequence encoding a malic enzyme and a method for preparing succinic acid using the same, more particularly, a maeB nucleotide sequence encoding a malic enzyme B having the activity of converting pyruvic acid or pyruvate to malic acid or malate, or vice versa, a recombinant vector containing the gene, a microorganism transformed with…
US 7491528 Method for extracellular production of target proteins employing OmpF in E. coli
The present invention provides an expression vector comprising genes encoding OmpF of E. coli and a desired protein, E.coli transformed with the expression vector, and a method for extracellular production of desired proteins by employing the same. The recombinant expression vector of the invention comprises an ampicillin-resistance gene, the OmpF…
US 7595156 Genes for Synthesis of FR-008 Polyketides
The present invention relates to the base sequence of whole genes involved in the biosynthesis of FR-008 polyketides derived from Streptomyces sp. FR-008. This base sequence comprises genes coding for ketosynthase (KS), acyl transferase (AT), acyl carrier protein (ACP), ketoreductase (KR), dehydratase (DH) and enoyl reductase (ER) domains, and…
US 6531446 Antimicrobial Peptides
The present invention relates to peptides that are more potent than or equally potent as the conventional antimicrobial peptides and has strong antimicrobial activities at high salt concentration.
US 6524344 Cement Coverings in Artificial Joint Stems and Systems
A cement jacket for a cemented artificial joint stem, the cement jacket including a main body with a hollow interior and an open upper end for receiving and enclosing at least a part of a stem of an artificial joint, the cement jacket being shaped and adapted for longitudinal insertion in an opening formed in a bone canal of a human body, the…
US 6184346 Protease Inhibitors Derived from Guamerin
The present invention relates to peptides inhibiting elastase and subtilisin activity, which are derived from Guamerin, an elastase-inhibiting protein isolated from a Korean leech, Guameri(Hirudo nipponia). Since the peptides of the invention permit their convenient synthesis and use, it can be applied for the development of elastase- and…
US 6316594 Antimicrobial peptide isolated from parasilurus asotus and its uses
Disclosed is a novel antimicrobial peptide, named parasin I, which is isolated from catfish. Catfish produce a strong antimicrobial peptide in the epithelial mucosal layer upon epidermal injury to protect against the invasion of microorganisms. It is 2000.4 Da in molecular mass and consist of 19 amino acid residues, represented by…
US 8067552 Method for preparing a target protein using the sHSPs
The present invention relates to a method for separating and purifying a target protein, a method for preparing a target protein, and a method for bioconversion by a whole cell enzyme or a partially purified enzyme. According to the present invention, when the sHSPs are added in cultivation, separation and purification processes for preparing a…
Disclosed are (i) a boron-dipyrrin compound having thienyl groups, (ii) a preparation method thereof and (iii) a chemosensor comprising the boron-dipyrrin compound having thienyl groups. More particularly, the present invention provides a boron-dipyrrin compound having thienyl group, furyl (OC4H3) group or selyl (SeC4H3) group, which is…
Mechanisms regulating cell proliferation stop and differentiation initiation during the development stage of mammalian embryo, and the proteins involved therein, are presented. Differentiation regulators, methods of regulating differentiation, transgenic organisms with loss of expression of the differentiation regulator, and methods of preparing…
The present invention relates to a method for secreting and producing a target protein into cell culture broth. More particularly, the invention relates to a microorganism co-transformed with a recombinant expression vector containing E. coli outer membrane protein F (OmpF) and a recombinant expression vector containing a target protein to be…
The present invention relates to a gene construct which is capable of achieving efficient production of an antimicrobial peptide in a microorganism, and a method for efficient mass production and separation of an antimicrobial peptide using the same. The gene construct of the present invention has a translationally coupled configuration of two…
US 7517654 Peptide and a derivative thereof promoting cell adhesion and spreading
The present invention relates to a peptide promoting cell adhesion and spreading, fragments, and derivatives thereof, more particularly, integrin-α3β1-dependent peptide in human laminin-5 α3 chain LG3 domain, mediating integrin α3β1 binding and cell adhesion and spreading, fragments and derivatives thereof. The inventive peptide, fragments…
The present invention provides a process for preparing thiazole derivatives of formula (XI), that activate the delta subtype of the human Peroxisome Proliferator Activated Receptor (hPPAR.delta.), and also provides processes for compounds of formula (VI), (VII), (VIII) and (IX), intermediate compounds for preparation of the above compounds of…
US 7482134 Signals and Molecular Species Involved in Senescence
The present invention relates to (a) a method for detecting a senescent cell, which comprises measuring a relative alteration to young cell in a signal or molecular species involved in signal transduction; (b) a method; and (c) a composition for modulating cellular senescence comprising treating a senescent cell with the effective amount of an…
US 8084399 Pocess for Screening of a Binding Amphiphilic Peptides Specific for Haiprin RNA
The present invention relates to a screening method of an amphiphilic peptide specifically binding to hairpin RNA, more precisely a screening method of an amphiphilic peptide having specificity and strong binding strength to target hairpin RNA using peptide library comprising those peptides having modifications of both hydrophilic face and…
US 7960345 Angiogenesis Inhibitor Comprising Meteorin as an Active Ingredient
The present invention relates to an angiogenesis inhibitor comprising meteorin as an active ingredient that is highly expressed in astrocytes of the brain and retina in the late embryonic stage and after the birth of a mouse. It is in particular highly detected in astrocyte endfeet surrounding blood vessels and promotes the expression of…
US 7476540 Monoclonal Antibodies to Mesenchymal Stem Cells
The present invention relates to monoclonal antibodies specifically binding to a membrane antigen of human mesenchymal stem cells, hybridoma cell lines producing the same, and methods for identifying or isolating human mesenchymal stem cells using the same. The monoclonal antibodies of this invention exhibit excellent specificity to human…
The present invention provides a process for preparing thiazole derivatives of formula (I), that activate the delta subtype of the human Peroxisome Proliferator Activated Receptor (hPPAR .delta.), and also provides compounds of formula (II), (IV), (X), (XI) and (XII), intermediate compounds for preparation of the above compounds of formula…
US 7525001 Process for Preparation of 2,6-dialkyltetralin
The present invention provides a novel process for highly selective preparation of 2,6-dialkyltetralin, a key precursor for 2,6-dimethylnaphthalene (2,6-DMN), which does not require an extra step for purifying various isomers obtained from the conventional processes for 2,6-DMN. The present invention is advantageous to improve the synthetic yield,…
US 7728194 DNA Fragment Specific to Cytoplasmic Male Sterile Ppepper and use thereof
The present invention relates to a DNA fragment specific to a cytoplasmic male sterile pepper comprising a polynucleotide of SEQ ID NO: 1, a candidate polynucleotide (named orf456) associated with cytoplasmic male sterile pepper consisting of a 223.sup.rd to 678.sup.th nucleic acid of SEQ ID NO:1, and a polynucleotide of SEQ ID NO: 2. The DNA…
US App 2007-0055072 Process for Preparing Guggulsterones and Guggulsterol
The present invention relates to a method for selective preparing 4,17 (20)-E-pregnadiene-3,16-dione (E-guggul-sterone) of the formula (III) and 4,17 (20)-Z-pregnadiene-3,16-dione (Z-guggulsterone) of the formula (IV) having an effect of lowering the elevated low density lipoprotein (LDL) and high levels of the cholesterol effectively, and…
The present invention provides a process for preparing thiazole derivatives of formula (XI), that activate the delta subtype of the human Peroxisome Proliferator Activated Receptor (hPPAR.delta.), and also provides processes for compounds of formula (VI), (VII), (VIII) and (IX), intermediate compounds for preparation of the above compounds of…
A preparation method of amyloid fibrils derived from alpha-synuclein, and a method using the same.
A technique for inhibiting biofouling caused by biofilms grown on a material surface of a water system where microorganisms exist such as the membrane surface of a membrane bioreactor (MBR) for advanced wastewater treatment is disclosed. Specifically, a magnetic carrier comprising an enzyme for quenching quorum sensing that inhibits biofilm…
Disclosed is a composition for treating dementia including shRNA to inhibit expression of S100a9. More particularly, the present disclosure describes a composition for prevention or treatment of dementia which includes shRNA having a nucleotide sequence defined by SEQ. ID No. 1 or 2 or a mixture thereof wherein the nucleotide sequence is…
US 7897722 Composition of Bone Formation with PHSRN-RGD Containing Oligopeptide
A PHSRN-RGD-containing oligopeptide and a composition for promoting bone formation, which contains such oligopeptide as an effective ingredient. The oligopeptide promotes osteoblastic cell adhesion and differentiation and enhances bone regenerative ability, so that the inventive oligopeptide can be effectively used in regenerative treatment of…
Provided is a pharmaceutical or food or drink composition for preventing or treating alcohol-induced fatty liver or steatohepatitis comprising metadoxine (pyridoxol 1-2-pyrrolidone-5-carboxylate) and garlic oil as active ingredients. The concurrent administration of metadoxine and garlic oil according to the present invention exhibits…
US 8003093 B cell-based vaccine loaded with the ligand of natural killer T cell and antigen
The present invention relates to a B cell-based vaccine loaded with the ligand of natural killer T cell and antigen for the prevention and treatment of disease, more precisely, an immunotherapeutic and prophylactic vaccine mediated by B cells loaded with .alpha.-galactosylceramide, a kind of glycolipid which can stimulate natural killer T cells. A…
US 8066978 Biopolymer and Gene Complex
Disclosed herein is a biopolymer/gene complex for the aerosol delivery of a gene. The biopolymer/gene complex comprises a polyethyleneimine (PEI) having a substitution of glucose for at least a portion of the primary amino groups of the polyethyleneimine, and the content of the polyethyleneimine is 2-4 times the content of the gene. Also,…
The present invention relates to a novel diaminedithiol derivative or a pharmaceutically acceptable salt thereof; radiorhenium or radiotechneticum complex thereof; a composition for treating liver cancer comprising the radiorhenium complex and lipiodol; and, a preparative kit of the composition for treating liver cancer. In the composition…
Disclosed is an inhibitor of replicative senescence of human keratinocytes containing retinoic acid, including all-trans retinoic acid, 3,4-didehydroretinoic acid, and 9-cis retinoic acid, as active ingredients. The retinoic acid plays an important role in extending the in vitro life span and inhibiting replicative senescence of the human mucosal…
Disclosed is a deodorizer composition comprising magnesium and calcium phosphate compounds, capable of effectively removing various malodorous components from the atmosphere.
Aminoacyl-tRNA synthetases are the enzymes catalyzing ligation of their cognate amino acids and tRNAs. Human glutaminyl-tRNA synthetase (QRS) consists of the unique N-terminal extension (236 aa) and the C-terminal catalytic domain (539 aa). Here, we found that the N- and C-domains of QRS interacted with pro-apoptotic mediator, Daxx, and its…
The present invention relates to a new use of medium-chain fatty acids in prevention and treatment of dental caries and a pharmaceutical composition containing medium-chain fatty acids as active ingredients. Particularly, the present invention relates to the use of the salt form of medium-chain fatty acids; nonanoic acid, capric acid, undecanoic…
US 8399044 Method for coating medication on medical article
The present invention relates to a method for coating a medical product with a sticky gel-type pharmaceutical substance, which can be easily applied on a silk or polypropylene product.
The tricarbonyl technetium-99m or rhenium-188 labeled ring RGD derivative has a high subnanomolar affinity to αvβ3 integrin, and is useful as a medicine for the diagnosis or treatment of angiogenesis-related diseases.
The present invention relates to a duplex vibriocidal assay capable of simultaneously measuring vibriocidal serum antibody titer with respect to each serotype when a combined Vibrio vaccine prepared by mixing two or more kinds of strains is evaluated after the combined vaccine is administrated.
PCT KR2011-008313 Polynucleotide for Diagnosing Sensitivity to Stomach Cancer
Apolynucleotide including a gene which is related to the metabolism of isoflavone, and especially a single-nucleotide polymorphism (SNP) that is induced from a gene which is on the signaling path of NF-κB, ERK, and AKT, or a reciprocal polynucleotide thereof as an indicative factor for diagnosing sensitivity to stomach cancer.
US App 20130274212 Sesterterpene Compounds and Use thereof
Sesterterpene compounds, to the precursors thereof that are hydrolysable in a living body, or to the pharmaceutically acceptable salts thereof, and also relates to the prevention and treatment efficacy of the sesterterpene compounds with respect to non-insulin dependent diabetes mellitus, diabetic complications, alcoholic,…
US App 20130197043 Use of the Fetal Reprogramming of a PPAR δ agonist
The PPAR δ agonist can be used in a pharmaceutical composition for enhancing the endurance of a human and an animal by embryonic/fetal reprogramming, preventing/inhibiting metabolic diseases such as obesity, diabetes, arteriosclerosis and fatty liver, and enhancing memory.
The present invention relates to a composition for the prevention and treatment of fatty liver diseases, comprising serine as an active ingredient.
The present invention relates to antifungal composition showing excellent anti-fungal activity specifically to fungus of Genus Ganoderma.
US App 8506937 Artificial Saliva Comprising Hyaluronic Acid
Provided is artificial saliva including hyaluronic acid (HA) useful for the treatment of xerostomia or oral candidiasis.
Provided is a lipid emulsion having krill oil, and the lipid emulsion can be used independently for oral/parenteral administration or as a daily nutrient.
The present invention is related to a composition comprising the ajoene-abundant garlic extract or ajoene isolated therefrom for treating or preventing the disease caused by over-expression or hyper-activation of LXR-alpha or SREBP-1.
A CDK-inhibiting pyrrolopyrimidinone carboxamide derivative or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition containing same as an active ingredient for preventing or treating liver cell cancer.
US App 20130184331 Treatment of Neurodegenerative Diseases by Targeting miRNA
The antisense oligonucleotide of the present invention inhibits the function of miR-206 to greatly increase the levels of BDNF and IGF-1 and to increase the regeneration of synapses, thereby treating neurodegenerative diseases, particularly Alzheimer’s disease.